Research in Sports Medicine and Technology

Compare of Two Aerobic Training Methods on SOD and TNF-α levels in the Heart Tissue of Type 2 Diabetic Rats

Authors

Ali Barzegari 1
Saeid Naghibi 1
Samaneh Safayi 1
Mohammadhasan Dashti Khovidaki 1
Anahita Salehi 2

1 Payame Noor University

2 Tabari University

Abstract
The purpose of this study was to compare two methods of aerobic exercise on the levels of SOD and TNF-α in the heart tissue of diabetic rats. 40 male Wistar rats aged ten weeks were randomly divided into four groups of 10: healthy control, diabetes, diabetes+MIT and diabetes+HIT. The moderate intensity training group ran 5 sessions per week for 8 weeks on the treadmill for 60 minutes at a speed of 25 meters per minute, and the high intensity training group also 5 sessions per week for 8 weeks with a training time of 60 minutes and at a speed of 34 meters per minute. The heart tissue of rats was examined to determine the amount of changes in SOD and TNF-α using ELISA method. To investigate the difference between groups of variables, one-way analysis of variance and Tukey's post hoc statistical tests were used at the significance level of P≥0.05. The results showed that there was a significant difference in the levels of TNF-α and SOD in the heart tissue of rats among the four research groups (P≤0.001). The levels of TNF-α in the HIT training group also showed a significant decrease compared to the diabetic group (P=0.001), While these changes in the MIT exercise group compared to the diabetes group was a non-significant decrease (P=0.117), the amount of SOD levels between the MIT and HIT exercise groups also showed a significant increase compared to the diabetic group (P=0.001). It seems, aerobic exercise with different intensities can improve SOD and TNF-α levels. Although the intensity of exercise in periodic exercise has been an effective factor in changing the values of both variables.

Keywords

diabetes
MIT
HIT
SOD
TNF-α
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!!! INVALID CITATION !!! {Sabouri, 2021 #4140;Soleymani, 2022 #4491}.
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