پژوهش در طب ورزشی و فناوری

بررسی تاثیر یک دوره تمرینات ورزشی ترکیبی بر میزان سایتوکاین اینترلوکین-17 و عملکرد شناختی در زنان دیابتی

مقالات آماده انتشار

نویسندگان

سمانه آقامحمدی 1
مهدیه ملانوری شمسی 1
حسین ادیبی 2

1 دانشگاه تربیت مدرس

2 دانشگاه علوم پزشکی تهران

چکیده
مقدمه: دیابت یک بیماری متابولیک و پیشرونده است که باعث فعال شدن سیستم ایمنی و افزایش برخی از سایتوکاین های التهابی از جمله IL-17 می شود. یکی از عوارض مرتبط با دیابت، بر مغز و سیستم عصبی است که با اختلال عملکرد شناختی مشخص می شود. فعالیت های ورزشی در بهبود شرایط بیماران دیابتی موثر است. هدف از مطالعه، بررسی تاثیر یک دوره ورزش ترکیبی چند وجهی در منزل بر سطوح سرمی سایتوکاین اینترلوکین17و عملکرد شناختی در زنان مبتلا به دیابت نوع دو بود.

روش‌ها: 70 بیمار مبتلا به دیابت نوع دو به صورت تصادفی به دو گروه تمرین و کنترل تقسیم شدند.گروه تمرین در یک برنامه تمرینات ورزش ترکیبی چندوجهی به مدت 3 ماه در منزل شرکت کردند. قبل و بعد از مداخله شاخص های خونی، عملکرد شناختی و ترکیب بدن اندازه گیری شد. از نرم افزار آماری SPSS برای تحلیل نتایج استفاده شد، سطح معناداری 0.05>P در نظر گرفته شد.

یافته‌ها: مطالعه حاضر نشان داد، تمرینات ترکیبی باعث کاهش سایتوکاین التهابی IL-17 شد (P<0.05). بررسی عملکرد شناختی هر چند بهبود نسبی را نشان داده است اما نتایج معنادار نمی باشد (P>0.05). همزمان قند خون ناشتا در گروه تمرین کاهش یافته است (P<0.05) و برخی از شاخص های مرتبط با ترکیب بدن و به صورت ویژه درصد چربی بهبود یافت (P<0.05).

نتیجه گیری: تمرینات ورزشی ترکیبی در منزل با کاهش سایتوکاین التهابی IL-17 و بهبود نسبی عملکرد شناختی در بیماران دیابتی همراه بود. بهبود احتمالی در پاسخ های ایمنی به دنبال این تمرینات می تواند در کاهش IL-17 سرمی موثر باشد.

عنوان مقاله English

Investigating the effect of combined exercise training on the level of interleukin-17 cytokine and cognitive function in type 2 women

نویسندگان English

Samaneh Agha-Mohammadi 1
Mahdieh Molanouri Shamsi 1
Hosain Adibi 2
1 Tarbiat Modares University
2 Tehran University of Medical Sciences
چکیده English

Introduction: Diabetes is a progressive metabolic disease that activates the immune system and increases certain inflammatory cytokines, including IL-17. One of the complications associated with diabetes affects the brain and nervous system, leading to cognitive dysfunction. Physical activities are effective in improving the condition of diabetic patients. This study aimed to investigate the effect of a multi-task combined home exercise program on serum levels of the cytokine interleukin-17 and cognitive function in women with type 2 diabetes.

Methods: Seventy patients with type 2 diabetes were randomly divided into two groups: exercise and control. The exercise group participated in a multi-task combined home-based exercise program for three months. Blood markers, cognitive function, and body composition were measured before and after the intervention. The results were analyzed using SPSS software, with a significance level of P<0.05.

Results: The present study showed that the combined exercise program led to a reduction in the inflammatory cytokine IL-17 (P<0.05). Although cognitive function showed relative improvement, the results were not statistically significant (P>0.05). Concurrently, fasting blood glucose decreased in the exercise group (P<0.05), and some body composition indices, particularly body fat percentage, improved (P<0.05).

Conclusion: Home-based combined exercise programs were associated with a reduction in the inflammatory cytokine IL-17 and a relative improvement in cognitive function in diabetic patients. The potential improvement in immune responses following these exercises may contribute to the reduction of serum IL-17 levels.

کلیدواژه‌ها English

type 2 diabetes
Interleukin 17
cognitive function
Combined Exercises
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پژوهش در طب ورزشی و فناوری

مقالات آماده انتشار، پذیرفته شده
انتشار آنلاین از 01 آبان 1398