پژوهش در طب ورزشی و فناوری

تأثیر تمرین مقاومتی و مصرف همزمان مکمل ویتامین D بر میزان فیلتراسیون گلومرولی و برخی از شاخص‌های سرمی عملکرد کلیوی در رت های نر مبتلابه نارسایی کلیوی

نویسندگان

سمیه مهدویان 1
فرشاد غزالیان 1
خسرو ابراهیم 2

1 دانشگاه آزاد اسلامی، واحد علوم تحقیقات، تهران

2 دانشگاه شهید بهشتی

https://doi.org/10.29252/jsmt.19.1.133
چکیده
هدف از مطالعه حاضر، بررسی تأثیر 8 هفته تمرین مقاومتی و مکمل ویتامین D بر برخی از شاخص‌های عملکرد کلیوی در رت­های نر مبتلابه نارسایی کلیوی بود. در این مطالعه تجربی، تعداد 16 سر موش صحرایی (7-8 هفته و میانگین وزن 350 تا 370 گرم) نر در چهار گروه (4=n): تمرین، گروه مکمل، گروه تمرین و مکمل و گروه کنترل قرار گرفتند. پس از القا آسیب کلیوی از طریق روش جراحی NX 6/5 و گذشت دو هفته، تمرین مقاومتی به مدت 8 هفته اجرا گردید. به‌صورت هم‌زمان نیز ویتامین D به میزان 1000 واحد در هفته به‌صورت عضلانی به رت‌ها تزریق گردید. در پایان، میزان تصفیه گلومرولی (با استفاده از مقادیر اوره و کراتینین) و سطوح سرمی ویتامین D، کلسیم و فسفر اندازه‌گیری شدند. برای تجزیه‌وتحلیل داده‌ها از آمار توصیفی و آزمون آنووا یک‌طرفه و آزمون تعقیبی توکی استفاده گردید. نتایج نشان داد، تصفیه گلومرولی و ویتامین D در گروه تمرین و مکمل در مقایسه با گروه کنترل و تمرین افزایش معنی‌داری نشان داد (0/05>P). این در حالی بود که مقادیر اوره و کراتینین و همچنین کلسیم و فسفر سرم کاهش معنی‌داری پیدا کردند (0/05>P). به نظر می‌رسد استفاده هم‌زمان از تمرینات مقاومتی و مکمل ویتامین D می‌تواند بر میزان فیلتراسیون گلومرولی مؤثر باشد.

کلیدواژه‌ها

تمرین مقاومتی
ویتامین D
تصفیه گلومرولی
نارسایی کلیوی

عنوان مقاله English

The effect of resistance training and vitamin D supplementation on some indicators of renal function in male rats with renal failure

نویسندگان English

Somaieh Mahdaviyan 1
Farshad Ghazalian 1
Khosro Ebrahim 2
چکیده English

The aim of this study was to investigate the effect of 8-weeks of resistance training and vitamin D supplementation on some indicators of renal function in male rats with renal failure. Methods: In this experimental study, 16 male rats (7-8 weeks and mean weight: 350 to 370 gr) were divided into four groups (n = 4): training, supplement, training and supplement and control group. After induction of kidney damage through NX 5.6 surgical method and two weeks later, resistance training was performed for 8 weeks. Simultaneously, 1000 unit of vitamin D per week intramuscularly was injected. Finally, glomerular purification (using urea and creatinine levels) and serum levels of vitamin D, calcium and phosphorus were measured. Descriptive statistics, one-way ANOVA test and Tukey post hoc test were used to analyze the data. The results showed that glomerular filtration and vitamin D in the training and supplementation groups showed a significant increase compared to the control and training groups (P<0.05). However, Urea and creatinine and serum calcium and phosphorus significantly was decreased (P<0.05). It seems that the simultaneous use of resistance training and vitamin D supplementation can affect glomerular filtration rate.

کلیدواژه‌ها English

Resistance Training
Vitamin D
Glomerular purification
renal failure
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